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      — In, hs4hmom wrote:
      > Ivermectin cannot be given to herding breed dogs.<<
      This thread has surfaced several times & for the sake of preventing another very long (& for many, a quite Frustrating!) thread, here is some additional information about this controversial subject.

      Side effects generally do not occur with any anti-mange doses of ivermectin except in Collies, Shetland sheepdogs, Australian shepherds, and Old English sheepdogs, though some individual animals that are not members of these sensitive breeds may also be prone to side effects.

      Very low test doses are often recommended to identify these individuals regardless of their breed. Collies with ivermectin sensitivity have been found to have a mutant gene for what is called the “P-glycoprotein.” The P-glycoprotein has been studied largely because overexpression of this protein (i.e.

      having more of it than normal) results poor function of chemotherapy drugs in the treatment of cancer. The P-glycoprotein appears to be involved in keeping drugs out of certain body tissues. Having excess P-glycoprotein keeps chemotherapy drugs from reaching the tumor; having a mutant/non-functional protein fails to keep medications like ivermectin out of the central nervous system.

      Approximately 35% of Collies appear affected by this condition. There is now a test for P-glycoprotein mutation so that ivermectin sensitive dogs can be identified.

      It should be noted that doses of ivermectin used for prevention and treatment of heartworm disease are approximately 50 times lower than doses used for other parasites. (Source:

      Collies & Ivermectin:

      Dosing Information: of the page)

      Please excercise caution when self medicating your pets!

      Also, it may help to search both the list archives and the budget101 Forums for previous threads for additional information regarding this topic.

      Best Wishes,


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